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Sydorchuk R.I.1, Fomin P.D.2, Olsson S.Д.3, Sydorchuk L.P. 1, Sydorchuk I.I. 1, Knut R.P. 1, Dykyy M.V. 1 Bucovinian State Medical Academy1, National State Medical university named after O,O, Bohomoletsm, Kyiv (Ukraine),2 Hospital Дngelholm-Helsigborg (Sweden)3. Background/aim: Abdominal sepsis (AS) is leading in terms of diagnostic, prophylactics, treatment complexity, and mortality amongst the most spread surgical diseases in elderly patients associated with digestive system. While the multiple organ dysfunction/failure syndrome (MODS), including hepatic insufficiency became even more significant in prognosis and treatment outcome, role of messenger/regulatory and metabolic changes under AS is growing. The aim of the study was to reveal changes of systemic aminotransferases activity under AS. Methods: Alaninaminotransferase [KF 2.6.1.2] (ALT) and aspartataminotransferase [KF 2.6.1.1] (ALT) activity we assessed dynamically using Kone®-Ultra system (U/l) in 52 AS patients (aged 41.933.47). Systemic inflammatory response syndrome (SIRS) associated with abdominal infection was a major criterion for AS diagnosis (R.C. Bone, 1996). All patients were divided accordingly into SIRS-2 (2 SIRS symptoms) – 1 group, SIRS-3 (3 SIRS symptoms) – 2nd, and SIRS-4 (4 SIRS symptoms, heavy sepsis) – 3rd group. 17 patient without abdominal pathology formed control group. Results/discussion: Correlative analysis showed the following: AST and ALT levels correlation in respective groups was 0.26 (control), 0.943 (1st group), -0.14 (2nd group) and 0.30 (3rd group). Correlation coefficients 0.64, -0.07 та –0.39 for ALT and –0.28, 0,80 та 0.17 – for AST characterized interrelations between different research groups. Conclusion: There is no doubt concerning development of hepatic dysfunction under AS. Although clinically expressed dysfunction/insufficiency was relatively rare (only 21.15%), this study shows that hepatic cytolysis syndrome under AS develops much earlier than clinical signs or laboratory marks occur. Lower than in 1st group results found in 3rd group during several periods may be associated with stimulated proteolysis activity mimicking less significant liver injury.