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Telehin D.1, Tychka I.2, Kondrat P.2 National Medical University of Lviv1, Lviv Regional Hospital2 Objectives: All consensus recommendation for the most critical need in hepatitis C and B research is to study the course and treatment of hepatitis in certain groups of population. The aim of this research is to study the clinical features and the long-term outcome of viral hepatitis in hemodialysis patients. Methods: 38 patients with acute viral hepatitis HBV- or/and HCV-etiology and with end stage chronic renal insufficiency who received hemodialysis were studied for 36 months. The control group – 50 patients with hepatitis of the similar etiologic structure without chronic renal failure. Activity of the pathological process, the time and intensity of immune response, duration of viremia and the incidence of hepatitis developing into a chronic form were compared. Results: The incidence of anicteric forms of hepatitis in dialysis patients and in a control group was 16,6% and 6,25% correspondingly. Hiperbilirubinemia level in those groups was correspondingly 116,923,7 mcmol/l against 269,320,9 mcmol/l and activity of GPT – 8,50,8 mmol/h•l against 15,31,0 mmol/h•l. HCVAb in dialysis population appeared later and their concentration was lower. Developing into a chronic hepatitis were observed in both investigated group more often (29% against 12%). Conclusion: The clinical course of hepatitis in patients with chronic renal failure are characterized by a high incidence of subclinical forms and a milder course of the disease with a tendency to develop into the chronic form. This can be due to a significant immune deficiency inherent to such patients, including delayed and weakened humorral response to the causative agent's antigens.